| Peer-Reviewed

The Incidence of Early Recurrence After Anatomical Versus Non-Anatomical Liver Resection in Patients with Hepatocellular Carcinoma

Received: 17 January 2018     Accepted: 26 January 2018     Published: 19 February 2018
Views:       Downloads:
Abstract

Aim: This retrospective study compares the incidence of early recurrence after anatomical versus non-anatomical resection in patients with hepatocellular carcinoma (HCC). Patients and Methods: This retrospective study included 26 patients who had a preoperative diagnosis of a single hepatocellular carcinoma (HCC) and who underwent anatomical and non-anatomical liver resection. The patients were divided into two groups. AR Group; anatomical resection group (n= 12) and NAR Group; Non-anatomical resection group (n = 14). The effect of the type of resection (anatomic vs non-anatomic) on early HCC recurrence was studied in both groups. Other risk factors that might play a role in early tumor recurrence such as the TNM staging, tumor size, vascular invasion, pathologic grading and high AFP values were also evaluated. Results: During the follow up period, 5 patients (41.7 %) from AR Group and 6 patients (42.9 %) from NAR Group developed recurrence. Mean time of recurrence was 13.05 ± 4.63 versus 12.53 ± 4.12 months (p 0.764). The univariate analysis method was used to analyze different epidemiological, clinical and pathological variables and there was no statistically significant risk factor in both groups in terms of recurrence. The mean disease-free survival was calculated for both groups using Kaplan–Meier curve and it was 16.013±2.324 for AR group versus 15.657±2.765 months for NAR group (p: 0.98). The cumulative overall survival proportion at end of research was 59.6% for AR group versus 69.87% for NAR group. The mean overall survival was 17.956±2.254 months for AR group versus 20.876±1.263 for NAR group (p: 0.21). The recurrence rate was 41.7%% in AR group and 42.9% in NAR group (p = 0.951). This suggests that the type of resection did not have an impact on early recurrence in HCC patients undergoing liver resection. Conclusion: This study concluded that recurrence-free and overall survivals after both anatomical and non-anatomical resection were not significantly different from the statistical point of view. Liver resection in cirrhotic patients should be performed with good expertise and should pursue strict selection criteria. Non-Anatomical resection may be more appropriate in cirrhotic patients with small HCC to preserve adequate functioning hepatic parenchyma and to avoid increased postoperative morbidity and mortality.

Published in Advances in Surgical Sciences (Volume 6, Issue 1)
DOI 10.11648/j.ass.20180601.12
Page(s) 7-15
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

HCC, Liver Resection, Local Recurrence, Anatomical Resection, Non-Anatomical Resection

References
[1] Cucchetti A, Qiao G-L, Cescon M, Li J, Xia Y, Ercolani G, et al. (2014): Anatomic versus nonanatomic resection in cirrhotic patients with early hepatocellular carcinoma. Surgery. 155 (3):512±21.
[2] Altekruse SF, McGlynn KA, Reichman ME. (2009): Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 27 (9):1485±91.
[3] Njei B, Rotman Y, Ditah I, Lim JK. (2015): Emerging trends in hepatocellular carcinoma incidence and mortality. Hepatology (Baltimore, Md). 61 (1):191±9.
[4] Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. (2011): Global cancer statistics. cancer journal for clinicians. 61 (2):69±90.
[5] Altekruse SF, Henley SJ, Cucinelli JE, McGlynn KA. (2014): Changing hepatocellular carcinoma incidence and liver cancer mortality rates in the United States. The American journal of gastroenterology. 109 (4):542±53.
[6] Dahiya D, Wu T-J, Lee C-F, Chan K-M, Lee W-C, Chen M-F. (2010): Minor versus major hepatic resection for small hepatocellular carcinoma (HCC) in cirrhotic patients: a 20-year experience. Surgery. 147 (5):676±85.
[7] Yamazaki O, Matsuyama M, Horii K, Kanazawa A, Shimizu S, Uenishi T, et al. (2010): Comparison of the outcomes between anatomical resection and limited resection for single hepatocellular carcinomas no larger than 5 cm in diameter: a single-center study. Journal of hepato-biliary-pancreatic sciences. 17 (3):349±58.
[8] Hasegawa K, Kokudo N, Imamura H, Matsuyama Y, Aoki T, Minagawa M, et al. (2005): Prognostic impact of anatomic resection for hepatocellular carcinoma. Annals of surgery. 242 (2):252±9.
[9] Regimbeau J-M, Kianmanesh R, Farges O, Dondero F, Sauvanet A, Belghiti J. (2002): Extent of liver resection influences the outcome in patients with cirrhosis and small hepatocellular carcinoma. Surgery. 131 (3):311±7.
[10] Hsia CY, Lui WY, Chau GY, King KL, Loong CC, Wu CW. (2000): Perioperative safety and prognosis in hepatocellular carcinoma patients with impaired liver function. Journal of the American College of Surgeons. 190 (5):574±9. PMID: 10801024.
[11] Yamanaka N, Okamoto E, Kawamura E, Kato T, Oriyama T, Fujimoto J, et al. (1993): Dynamics of normal and injured human liver regeneration after hepatectomy as assessed on the basis of computed tomography and liver function. Hepatology (Baltimore, Md). 18 (1):79±85.
[12] Kang CM, Choi GH, Kim DH, Choi SB, Kim KS, Choi JS, et al. (2010): Revisiting the role of nonanatomic resection of small (< or = 4 cm) and single hepatocellular carcinoma in patients with well-preserved liver function. The Journal of surgical research. 160 (1):81±9.
[13] Popescu I, Campeanu I. (2009): [Surgical anatomy of the liver and liver resection. Brisbane 2000 Terminology]. 104 (1):7±10.
[14] Makuuchi M, Imamura H, Sugawara Y, Takayama T. (2002): Progress in surgical treatment of hepatocellular carcinoma. Oncology. 62 Suppl 1:74±81.
[15] Kim YK, Han HS, Yoon YS, Cho JY, Lee W. (2015): Total anatomical laparoscopic liver resection of segment 4 (S4), extended S4, and subsegments S4a and S4b for hepatocellular carcinoma. Journal of laparoendoscopic & advanced surgical techniques Part A. 25 (5):375±9.
[16] Thuan N, Long TCD, Bac NH, Dat LT, Viet DQ. (2014): Glissonean pedicle transection for anatomic liver resection. HPB. 2014; 16:466.
[17] Kudo A, Tanaka S, Ban D, Matsumura S, Irie T, Nakamura N, et al. (2014): Anatomic resection reduces the recurrence of solitary hepatocellular carcinoma <= 5 cm without macrovascular invasion. American journal of surgery. 207 (6):863±9.
[18] Tomimaru Y, Eguchi H, Marubashi S, Wada H, Kobayashi S, Tanemura M, et al. (2012): Equivalent outcomes after anatomical and non-anatomical resection of small hepatocellular carcinoma in patients with preserved liver function. Digestive diseases and sciences. 57 (7):1942±8.
[19] Eltawil KM, Kidd M, Giovinazzo F, Helmy AH and Salem RR (2010): Differentiating the impact of anatomical and non anatomical liver resection on early recurrence in patients with Hepatocellular carcinoma: World J of Surg. Oncology 8:1-7.
[20] Tan Y, Zhaung W, Jiang L, Yang J and Yan L (2017): Efficacy and safety of anatomic versus non anatomic resection in patients with hepatocellular carcinoma: A systemic review and meta analysis. PloS ONE 12 (10):e0186930.
[21] Abdelhady H, Hossam I, Ismaeil T, Elsheikh M, Abdelwahab M Soliman M and Hassan O (2015): Anatomic versus non anatomic Hepatic resection for patients with stage I and II Hepatocellular carcinoma; Ain Shams J Surg 8 (2):151-162.
[22] Torzilli G, Makuuchi M, Inoue K, Takayama T, Sakamoto Y, Sugawara Y, Kubota K and Zucchi A. (1999): No-mortality liver resection for hepatocellular carcinoma in cirrhotic and noncirrhotic patients: is there a way? A prospective analysis of our approach. Arch Surg. 134:984–92.
[23] Regimbeau J. M., Kianmanesh R., Farges O., Dondero F., Sauvanet A. and Belghiti J. (2002): Extent of liver resection influences the outcome in patients with cirrhosis and small hepatocellular carcinoma. Surgery, 131: 311-7.
[24] Ziparo V., Balducci G., Lucandri G., Mercantini P., Giacomo G. and Fernandes E. (2002): Indications and results of resection for hepatocellular carcinoma. Eur J Surg Oncol, 28: 723-8.
[25] Cucchetti A, Piscaglia F, Caturelli E, Benvegnu L, Vivarelli M, Ercolani G, Cescon M, Ravaioli M, Grazi GL, Bolondi L and Pinna AD. (2009): Comparison of recurrence of hepatocellular carcinoma after resection in patients with cirrhosis to its occurrence in a surveilled cirrhotic population. Ann Surg Oncol. 16:413–22.
[26] Emond J. C. and Polastri R. (1996): Anatomical hepatectomy for resection or transplantation. Am J Surg, 172: 29-34.
[27] Mazziotti I A., Grazi G. L. and Ercolani G. (1997): Hepatic resective surgery in cirrhotic patients. Techniques and results of anatomical segmentectomies. Ann Ital Chir, 68: 781-90.
[28] Takayama T., Makuuchi M., Yamasaki S., Kosuge T., Yamamoto J. and Shimada K. (1998): Systematic resection for hepatocellular carcinoma. Jpn Surg Soc, 99: 241-4.
[29] Imamura H., Matsuyama Y. and Miyagawa Y. (1999): Prognostic significance of anatomical resection and des-gamma-carboxy prothrombin in patients with hepatocellular carcinoma. Br J Surg, 86: 1032-8.
[30] Imamura H., Matsuyama Y. and Tanaka E. (2003): Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy. J Hepatol, 38: 237-9.
[31] Shirabe K., Kanematsu T., Matsumata T., Adachi E., Akazawa K. and Sugimachi K. (1991): Factors linked to early recurrence of small hepatocellular carcinoma after hepatectomy: univariate and multivariate analysis. Hepatology, 14: 802-5.
[32] Scheele J. (2001): Anatomical and atypical liver resections. Chirurg. 72: 113-24.
[33] Kanematsu t., Takenaka k., Matsumata t., Furuta t., Sugimachi k. and Inokuchi k. (1984): Limited hepatic resection effective for selected cirrhotic patients with primary liver cancer. Ann Surg, 199: 51-6.
[34] Seheon K, Seokwhan K, Insaug S, Kwangsik C (2015): Comparison of survival outcomes after anatomical resection and non anatomical resection in patients with Hepatocellular carcinoma. Korean J Hepatobiliary Pancreatic Surg 19:161-166.
[35] Nanashima A, Sumida Y, Abo T, Nagasaki T, Tobinaga S, Fukuoka H, Takeshita H, Hidaka S, Tanaka K, Sawai T, Yasutake T and Nagayasu T. (2008): Comparison of survival between anatomic and non-anatomic liver resection in patients with hepatocellular carcinoma: significance of surgical margin in non-anatomic resection. Acta Chir Belg. 108 (5):532-7.
Cite This Article
  • APA Style

    Mohamed Abdallah Hablus, Osama Hasan Abd-Raboh. (2018). The Incidence of Early Recurrence After Anatomical Versus Non-Anatomical Liver Resection in Patients with Hepatocellular Carcinoma. Advances in Surgical Sciences, 6(1), 7-15. https://doi.org/10.11648/j.ass.20180601.12

    Copy | Download

    ACS Style

    Mohamed Abdallah Hablus; Osama Hasan Abd-Raboh. The Incidence of Early Recurrence After Anatomical Versus Non-Anatomical Liver Resection in Patients with Hepatocellular Carcinoma. Adv. Surg. Sci. 2018, 6(1), 7-15. doi: 10.11648/j.ass.20180601.12

    Copy | Download

    AMA Style

    Mohamed Abdallah Hablus, Osama Hasan Abd-Raboh. The Incidence of Early Recurrence After Anatomical Versus Non-Anatomical Liver Resection in Patients with Hepatocellular Carcinoma. Adv Surg Sci. 2018;6(1):7-15. doi: 10.11648/j.ass.20180601.12

    Copy | Download

  • @article{10.11648/j.ass.20180601.12,
      author = {Mohamed Abdallah Hablus and Osama Hasan Abd-Raboh},
      title = {The Incidence of Early Recurrence After Anatomical Versus Non-Anatomical Liver Resection in Patients with Hepatocellular Carcinoma},
      journal = {Advances in Surgical Sciences},
      volume = {6},
      number = {1},
      pages = {7-15},
      doi = {10.11648/j.ass.20180601.12},
      url = {https://doi.org/10.11648/j.ass.20180601.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ass.20180601.12},
      abstract = {Aim: This retrospective study compares the incidence of early recurrence after anatomical versus non-anatomical resection in patients with hepatocellular carcinoma (HCC). Patients and Methods: This retrospective study included 26 patients who had a preoperative diagnosis of a single hepatocellular carcinoma (HCC) and who underwent anatomical and non-anatomical liver resection. The patients were divided into two groups. AR Group; anatomical resection group (n= 12) and NAR Group; Non-anatomical resection group (n = 14). The effect of the type of resection (anatomic vs non-anatomic) on early HCC recurrence was studied in both groups. Other risk factors that might play a role in early tumor recurrence such as the TNM staging, tumor size, vascular invasion, pathologic grading and high AFP values were also evaluated. Results: During the follow up period, 5 patients (41.7 %) from AR Group and 6 patients (42.9 %) from NAR Group developed recurrence. Mean time of recurrence was 13.05 ± 4.63 versus 12.53 ± 4.12 months (p 0.764). The univariate analysis method was used to analyze different epidemiological, clinical and pathological variables and there was no statistically significant risk factor in both groups in terms of recurrence. The mean disease-free survival was calculated for both groups using Kaplan–Meier curve and it was 16.013±2.324 for AR group versus 15.657±2.765 months for NAR group (p: 0.98). The cumulative overall survival proportion at end of research was 59.6% for AR group versus 69.87% for NAR group. The mean overall survival was 17.956±2.254 months for AR group versus 20.876±1.263 for NAR group (p: 0.21). The recurrence rate was 41.7%% in AR group and 42.9% in NAR group (p = 0.951). This suggests that the type of resection did not have an impact on early recurrence in HCC patients undergoing liver resection. Conclusion: This study concluded that recurrence-free and overall survivals after both anatomical and non-anatomical resection were not significantly different from the statistical point of view. Liver resection in cirrhotic patients should be performed with good expertise and should pursue strict selection criteria. Non-Anatomical resection may be more appropriate in cirrhotic patients with small HCC to preserve adequate functioning hepatic parenchyma and to avoid increased postoperative morbidity and mortality.},
     year = {2018}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - The Incidence of Early Recurrence After Anatomical Versus Non-Anatomical Liver Resection in Patients with Hepatocellular Carcinoma
    AU  - Mohamed Abdallah Hablus
    AU  - Osama Hasan Abd-Raboh
    Y1  - 2018/02/19
    PY  - 2018
    N1  - https://doi.org/10.11648/j.ass.20180601.12
    DO  - 10.11648/j.ass.20180601.12
    T2  - Advances in Surgical Sciences
    JF  - Advances in Surgical Sciences
    JO  - Advances in Surgical Sciences
    SP  - 7
    EP  - 15
    PB  - Science Publishing Group
    SN  - 2376-6182
    UR  - https://doi.org/10.11648/j.ass.20180601.12
    AB  - Aim: This retrospective study compares the incidence of early recurrence after anatomical versus non-anatomical resection in patients with hepatocellular carcinoma (HCC). Patients and Methods: This retrospective study included 26 patients who had a preoperative diagnosis of a single hepatocellular carcinoma (HCC) and who underwent anatomical and non-anatomical liver resection. The patients were divided into two groups. AR Group; anatomical resection group (n= 12) and NAR Group; Non-anatomical resection group (n = 14). The effect of the type of resection (anatomic vs non-anatomic) on early HCC recurrence was studied in both groups. Other risk factors that might play a role in early tumor recurrence such as the TNM staging, tumor size, vascular invasion, pathologic grading and high AFP values were also evaluated. Results: During the follow up period, 5 patients (41.7 %) from AR Group and 6 patients (42.9 %) from NAR Group developed recurrence. Mean time of recurrence was 13.05 ± 4.63 versus 12.53 ± 4.12 months (p 0.764). The univariate analysis method was used to analyze different epidemiological, clinical and pathological variables and there was no statistically significant risk factor in both groups in terms of recurrence. The mean disease-free survival was calculated for both groups using Kaplan–Meier curve and it was 16.013±2.324 for AR group versus 15.657±2.765 months for NAR group (p: 0.98). The cumulative overall survival proportion at end of research was 59.6% for AR group versus 69.87% for NAR group. The mean overall survival was 17.956±2.254 months for AR group versus 20.876±1.263 for NAR group (p: 0.21). The recurrence rate was 41.7%% in AR group and 42.9% in NAR group (p = 0.951). This suggests that the type of resection did not have an impact on early recurrence in HCC patients undergoing liver resection. Conclusion: This study concluded that recurrence-free and overall survivals after both anatomical and non-anatomical resection were not significantly different from the statistical point of view. Liver resection in cirrhotic patients should be performed with good expertise and should pursue strict selection criteria. Non-Anatomical resection may be more appropriate in cirrhotic patients with small HCC to preserve adequate functioning hepatic parenchyma and to avoid increased postoperative morbidity and mortality.
    VL  - 6
    IS  - 1
    ER  - 

    Copy | Download

Author Information
  • General Surgery Department, Faculty of Medicine, Tanta University Hospitals, Tanta, Egypt

  • General Surgery Department, Faculty of Medicine, Tanta University Hospitals, Tanta, Egypt

  • Sections