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Ameliorative Effect of Ethanolic Extract of Tigernut on Aluminium Chloride Induced Pancreatic Histomorphological Changes on Adult Wistar Rats

Background: Tiger nut tuberis very common and abundant in Nigeria. Aluminium chloride is the third must abundant metal present naturally on earth crust. Objective: The objective of thestudy was to assess the increase in rate of aluminium chloride exposure and toxicity on the pancreas of adult wistar rats. Aim: To evaluate the protective effect of ethanolic extract of tigernut on pancreas of adult wistar rats. Methods: In this study twenty five adult rats were used. The animals were grouped into a control group A and treatment groups B, C, D and E. Group A served as control and was administered orally with normal saline, group B wasadministered orally with 500 mg/kg of aluminum chloride, group C, D and E were administered with 1250 mg/kg of the ethanolic extract of Cyperus esculentus only, 500 mg/kg of aluminum chloride followed by 2500 mg/kg of the ethanolic extract of Cyperus esculentus and 500 mg/kg of aluminum chloride followed by 3750 mg/kg of the ethanolic extract of Cyperus esculentus respectively. The treatment was for six weeks, weights of the rats were recorded weekly. Result: The histo-morphology of the pancreas revealed that group A showed the normal pancreatic histo-architecture, group B showed sign of inflammation and paucity of islet cells. Groups C, D and E showed normal pancreatic histomorphology. Conclusion: Tissue exposed to aluminum chloride showed fibrosis and inflammation due to toxicity while those exposed to tiger nut therapy showed recovery and regeneration of damaged cells thus indicating ameliorative role of tigernut seed.

Ameliorative, Tigernut, Ethanolic Extract, Pancreas, Wistar Rats

Gudaji Abdullahi, Umar Zailani. (2023). Ameliorative Effect of Ethanolic Extract of Tigernut on Aluminium Chloride Induced Pancreatic Histomorphological Changes on Adult Wistar Rats. Advances in Surgical Sciences, 11(1), 17-21.

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This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

1. Bamishaiye, E. I. and Bamishaiye, O. M. (2011). Tigernut. Asaplant, its derivative sand benefits. African Journal of Food, Agriculture and Nutritional Development, 11 (5): 5157-5170.
2. Sanchez-Zapata, E., Fernandez-Lopez, J. and Angel P. J. (2012). Tigernut (Cyperus esculentus) commercialization: health aspects, composition, properties, and food applications. Comprehensive Reviews in Food Science and Food Safety. 11 (4): 36677.
3. Okafor, J. N. C., Mordi, J. I., Ozumba, A. U., Solomon, H. M. and Olatunji, I. (2003).
4. Umerie, S. C. and Enebeli, J. N. (1997). Maltcaramel from the nuts of Cyperus esculentus. Journal of Biological Resources and Technology, 8: 215-216.
5. Belewu, M. A. and Belewu, K. Y. (2007). Comparative physico-chemical evaluation of tiger nut, Soybean and coconut milk source. International journal of Agriculture and Biology, 9: 785-787.
6. Oladele, A. K., K. and Aina, J. O. (2007). Chemical composition and functional properties of flour from two varieties of tiger nut (Cyperus esculentus). African Journal of Biotechnology 6 (21): 2473-2476.
7. Arafat, S. M., Gaafar, A. M., Basuny, A. M. and Nassef S. L. (2009). Chufa tubers (Cyperus esculentus) As a new source of food. World Applied Sciences Journal, 7 (2): 151-156.
8. Dhouha, K., Diana, A. A., Mokhtar, Z. &Iciar, A. (2016). Review on Cyperus esculentus: from food safety to pharmacotherapeutics. International Journal of Pharmaceutics, 6 (2): 71-81.
9. Muhammad, N. O., Bamishaiye, E. I., Bamishaiye, O. M., Usman, L. A., Salawu, M. O., Nafiu, M. O, and Oloyede, O. B. (2011). Physicochemical properties and fatty acid composition of Cyperus esculentus (Tigernut) tuber oil. Bioresearch Bulletin. 5: 51-54.
10. Singh, V., (2014). Textbook of Anatomy Abdomen and Lower limb. Elsevier. Pp 5.
11. Ali, O. I. and Amin, I. M. (2006). Toxicological appraisal of some heavy metals level in water of treated with lead acetate. International Journal of Drug Development and Research, 20-13.
12. Verstraeten, S. V., Aimo, L. and Oteiza, P. I. (2008). Aluminum and lead: molecular mechanisms of brain toxicity, Archieves of Toxicology, 82 (11) 789-802.
13. Campbell, A., (2002). The potential role of aluminium in Alzheimer’s disease. Nephrology, Dialysis and Transplantation, 17 suppl. 2 (2): 17-20.
14. Chukwuma, E. R., Obioma, N. and Christopher, O. I. (2010). The phytochemical composition and some biochemical effects of Nigerian tigernut (Cyperus esculentus L.) tuber. Pakistan Journal of Nutrition. 9 (7): 709-15.
15. Mason, D Tiger Nuts In: Accessed December, 2009.
16. Seyran, E. A. and Thong, M. O. (2017). Tigernut (Cyperus esculentus): Some natural anticancer drug? Brief Review of existing literature. Euromediterranean Biomedical Journal, 12 (19): 91-94.
17. Alegria-Toran, A. and Farre-Rovira, R. (2003). Horchata y salud: Aspectosnutricionales y diet´eticos. In: Fundaci´on Valenciana de Estudios Avanzados, editor. Jornada Chufa y Horchata: Tradici´on y Salud. Valencia, Spain: Conseller´ıa de Agricultura, Pesca y Alimentaci´on. p. 55-70.
18. Martinez-Valls, J. F. (2003). Horchata y Salud: Posiblesbeneficios de la horchata de chufa en la prevenci´on de la arteriosclerosis. In: Jornada Chufa y Horchata: Tradici´on y Salud, editor. Fundaci´onValenciana de EstudiosAvanzados. Valencia, Spain: Conseller´ıa de Agricultura, Pesca y Alimentaci´on. p. 87-94.
19. Chevallier, A. (1996). The Encyclopedia of medicinal plants. Dorling Kindersley Press London. 48-51.
20. Mekapogu, A. R., Pothula, S. P., Pirola, R. C., Wilson, J. S. and Apte, M. V. (2020). Pancreatic Stellate Cellsin Health and Disease. The Pancreapedia: Exocrine Pancreas Knowledge Base. DOI: 10.3998/panc.2020.08.
21. Yokel, R. A. and Mc Namara, P. J. (2001). Aluminum toxicokinetics: an updated mini review. Pharmacological Toxicology, 88: 159-167.
22. Kumar, V., Bal, A., and Gill, K. D. (2009). Susceptibility of mitochondrial superoxide dismutase to aluminium induced oxidative damage. Tox., 255 (3), 117-123.
23. Reiter, R. J., Tan, D. X., Terron, M. P., Flores, L. J., & Czarnocki, Z. (2007). Melatonin and its metabolites: New findings regarding their production and their radical scavenging actions. ActaBiochimica Polonica-English Edition, 54 (1): 1.
24. Grover, J. K., Yadav, S. P. and Vats, V. (2002). Medical plants in India with anti-diabetic potential. Journal of Ethnopharmacology, 81: 81-100.
25. Kalaiselvi, A., Aadhinath, Reddy, G. and Ramalingam, V. (2015). Ameliorating effect of ginger extract (Zingiberofficinale Roscoe) on liver marker enzymes, lipid profile in aluminium chloride induced male rats. International Journal of Pharmaceutical Sciences and Drug Research, 7: 52-8.
26. Wei, Q., Yan, X. X., Ma, Z. X., Ou, Y. and Jing, S. Q. (2008). Extraction and analysis of cyperus esculentus oil in Xinjiang. Food Science Technology, 35: 226.